The boos from the crowd were deafening as Peter Bankes and the officials made their way off the field at half-time.
Even Joe Willock, who had not even come on at that point, made his feelings clear, having felt aggrieved with Ramsey's red card and the amount of stoppage time added on in the first half.
Ten-man Newcastle could have lost their composure, but you would not have known the hosts were playing with a man fewer in the second half.
Nothing quite said that like William Osula racing down the right flank, cutting inside Tyrell Malacia and letting fly with an absolute rocket to leave Howe roaring in delight on the touchline.
To describe Osula as an unlikely match-winner may seem a strange description for a forward, but he had not scored since September and failed to take his chance during a rare start against Qarabag last week.
Yet this was a night where Eddie Howe's big calls paid off - and he needed them to following a run of five defeats in six Premier League games.
As well as Osula repaying his faith, after his introduction at a crucial juncture of the game, so, too, did Aaron Ramsdale at the other end of the field on his first league start since December.
Leaky Newcastle have struggled to keep the opposition out, and were not 1-0 up for long, but the hosts limited Manchester United's in-form front line and Ramsdale was there to make a couple of big saves to ensure Howe's team did not fall behind.
This fixture has so often brought the best out of Howe's side - he will take encouragement from the spirit and resilience his team played with.